A developmental biologist muses about stem cells and regenerative medicine, the ethics of it all and the possibilities.
The olfactory epithelium lines the posterodorsal nasal cavity immediately inferior to the cranial cavity. The normal epithelium is composed of a handful of cell types: sustentacular cells (Sus), microvillar cells (a supporting cell variant), olfactory sensory neurons – both mature and immature (OSNs), globose basal cells (GBCs), horizontal basal cells (HBCs), Bowman’s duct and gland cells. Deep to the basal lamina, the fascicles of the olfactory axons are ensheathed by the specialized glia of the olfactory nerve, the olfactory ensheathing cells (OECs). In addition, stromal cells (fibroblasts) of the lamina propria secrete signals that regulate epithelial assembly and turnover.