A protocol for direct reprogramming of fibroblasts into motor neurons

A very efficient protocol for directly reprogramming skin-based fibroblasts into neurons is provided at this link. The induced neurons have all the electrophysiological characteristics of normal neurons and because no embryonic stage is passed through, these cells are safer than iPSCs. The problem is making enough of them for therapeutic purposes. At this point, the iPSCs really have it hands down.

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Professor of Biochemistry at Spring Arbor University (SAU) in Spring Arbor, MI. Have been at SAU since 1999. Author of The Stem Cell Epistles. Before that I was a postdoctoral research fellow at the University of Pennsylvania in Philadelphia, PA (1997-1999), and Sussex University, Falmer, UK (1994-1997). I studied Cell and Developmental Biology at UC Irvine (PhD 1994), and Microbiology at UC Davis (MA 1986, BS 1984).

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