CAR T-Cell Therapy Surpasses 90% Complete Remission Rate in Pediatric ALL


The chimeric antigen receptor (CAR) T-cell therapy JCAR017 elicited a 91% complete remission rate in pediatric patients with relapsed/refractory acute lymphoblastic leukemia (ALL), according to results from a phase I trial presented at the 2015 AACR Annual Meeting.

In the treated patients, complete remissions were observed in 20 of 22 patients, as ascertained by flow cytometry.  Complete remissions were observed with all applied doses of JCAR017 and in patients who had been treated already with CD19-targeted therapies.  Severe neurotoxicity and/or severe “cytokine release syndrome” was observed in 8 patients. In total, 4 patients have relapsed—only one of which had CD19-positive disease.

“The 91% remission rate in this phase I study of JCAR017 is highly encouraging, particularly when considering these pediatric patients failed to respond to standard treatments,” Michael Jensen, MD, said in a statement. “Based on these results we are eager to advance this study, and to continue advancing the use of cell therapies to change how we treat cancer and provide patients the opportunity for better treatment options.”

Jensen serves as the director of the Ben Towne Center for Childhood Cancer Research at Seattle Children’s Research Institute, and is also the scientific co-founder of Juno Therapeutics, which is the company that is developing JCAR017.  JCAR017 is being evaluated in an ongoing phase I/II study for pediatric and young adult patients with relapsed/refractory CD19-positive leukemia at the Seattle Children’s Hospital.

This  study intends to enroll 80 patients.  The phase I portion enrolled patients who had undergone an allogeneic hematopoietic cell transplant, but the second phase of the study is open to patients, regardless of prior transplant status (NCT02028455).

“Given the impressive clinical results with this defined cell product candidate, we are encouraged to begin testing of JCAR017 in adult patients with B cell malignancies, including non-Hodgkin lymphoma, later this year,” Hans Bishop, chief executive officer of Juno Therapeutics, said in a statement.

Juno also has three other CAR and T cell receptor therapies that are under evaluation in clinical trials.  The furthest along is JCAR015, which received a breakthrough therapy designation from the FDA as a treatment for patients with relapsed or refractory B-cell ALL in November 2014.  In one trial, JCAR015 is being used to treat precursor B cell ALL, which is the condition for which JCAR015 was awarded its orphan drug designation (NCT01840566).  In a second trial, patients with relapsed/refractory aggressive B cell non-Hodgkin lymphoma (NHL) are being treated with high dose therapy and autologous stem cell transplantation followed by infusion of JCAR015 (NCT01044069).

There are plans for future clinical trials to explore Juno’s CAR T cell therapies in combination with immune checkpoint inhibitors. Recently, Juno and MedImmune, the biologics research and development arm of AstraZeneca, announced an agreement focused on the clinical development of combination strategies.  A jointly-funded phase Ib study will explore one of Juno’s CD19-directed CAR T cell therapies in combination with the PD-L1 inhibitor MEDI4736 as a treatment for patients with NHL.  It is expected to begin later this year.

“We believe combination strategies such as this will help us better understand the full potential of our engineered T cell platform in both hematological and solid tumor settings,” Mark W. Frohlich, MD, executive vice president, Research & Development, Juno Therapeutics, said in a statement.

MEDI4736 is currently under evaluated in phase III clinical trials that are testing MEDI4736 alone and in combination with the CTLA-4 antibody tremelimumab in patients with a variety of non-small cell lung cancers and in patients with head and neck cancer who have failed prior chemotherapy.

Competition in the field of immuno-oncology has resulted in collaborations between several pharmaceutical companies, outside of the Juno deal. This is evident in the field of CAR-modified T-cell therapy, where collaborations exist between Novartis and the University of Pennsylvania (CTL019) and between Kite Pharma and the NCI (KTE-C19).

In the pediatric oncology space, results from the breakthrough therapy CTL019 were presented at the 2014 ASH Annual Meeting and demonstrated similar findings to those announced for JCAR017. In this phase I trial of 39 pediatric patients with relapsed/refractory ALL, CTL019 demonstrated a 92% complete remission rate. In total, 85% of patients who achieve a complete remission tested MRD-negative by flow cytometry.

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mburatov

Professor of Biochemistry at Spring Arbor University (SAU) in Spring Arbor, MI. Have been at SAU since 1999. Author of The Stem Cell Epistles. Before that I was a postdoctoral research fellow at the University of Pennsylvania in Philadelphia, PA (1997-1999), and Sussex University, Falmer, UK (1994-1997). I studied Cell and Developmental Biology at UC Irvine (PhD 1994), and Microbiology at UC Davis (MA 1986, BS 1984).