The founders of the Riordan-McKenna Institute, Neil Riordan, PhD and orthopedic surgeon, Wade McKenna, DO, have announced that the use of sterile, dehydrated amniotic tissue AlphaPATCH™, which was developed by Amniotic Therapies in Dallas, Texas, resulted in complete healing of an otherwise non-healing surgical knee wound.
The case involved a 78-year-old male who had a non-healing surgical wound from a total right knee replacement that had been performed six weeks earlier. The patient had not responded after 6 weeks of conservative wound care and the wound showed no signs of healing.
Dr. McKenna irrigated the wound in the operating room and then placed two AlphaPATCH dry amniotic membranes (4 cm x 4 cm) over the wound before dressing it.
At the two-week follow-up visit, a central scab had formed over the wound. At four-weeks, the wound had completely scabbed over, and by eight-weeks, the scab had just fallen off and the wound was healing well, covered by a patch of immature skin about the size of a penny. At the ten-week follow-up visit, the wound was completely healed.
The case report, entitled “Case Report Of Non-Healing Surgical Wound Treated With Dehydrated Amniotic Membrane” is published in the July issue of the Journal of Translational Medicine. This milestone in Dr. Riordan and Dr. McKenna’s ongoing study of the use of amniotic tissue products and stem cells to stimulate or augment wound healing is the third peer-reviewed journal article on regenerative medicine published by the Riordan McKenna Institute.
Dehydrated amniotic membrane products like AlphaPATCH is thought by most people to contain live stem cells, which is not the case. However, dehydrated amniotic membrane does contain several growth factors that promote healing and stimulate the body’s own stem cells to behave more similar to stem cells in a younger person.
“It’s gratifying to have this new tool in my toolbox. I treated conservatively and was getting nowhere. Even in a patient with a significant smoking history and decreased blood flow to his legs, we were able to achieve this result. Chronic wounds can be very frustrating for both the patient and the caregiver,” remarked Troy Chandler, PA-C, who participated in the patient’s treatment.