Engineered Brown Fat For Metabolic Disorders


BioRestorative Therapies, Inc, (BRTX) has announced what they termed as “promising data” on the transplantation of human stem cell-derived tissue engineering from brown fat.

This study is in a meeting abstract at the moment, so there is no paper to reference at the time. The presentation entitled, “In Vitro Evaluation of an Encapsulation System for the Transplantation of Human Stem Cell-Derived Tissue Engineered Brown Fat,” was given at the International Society for Cellular Therapy meeting in Singapore.

In a nutshell, BRTX scientists examined a technique in which they isolated brown fat-derived stem cell populations, and then differentiated those cells in a step-wide fashion into three-dimensional brown fat assemblages. These brown fat constructs were loaded into tiny microcapsules that can potentially deliver these cells into the tissues of a living organism.

Brown fat cells possess a protein called UCP-1 (Uncoupling Protein-1). This protein short circuits the energy producing machinery of cells and converts that energy into heat instead of the energy-storing molecule ATP. Thus, brown fat cells burn more calories than show regular fat cells and generate a good deal more heat. Increasing brown fat levels in a patient with a weight problem could, in theory, at least, cause that patient to inherently burn more calories.

The laboratory-derived, encapsulated brown fat cells seemed to excellent survival and also expressed respectable amounts of UCP-1.

BRTX would like to, someday, transplant these encapsulated cells into human patients someday, but before that day comes, a good deal of animal experiments are required to demonstrate the safety and efficacy of this product. Then and only then will human experiments be warranted.

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Published by

mburatov

Professor of Biochemistry at Spring Arbor University (SAU) in Spring Arbor, MI. Have been at SAU since 1999. Author of The Stem Cell Epistles. Before that I was a postdoctoral research fellow at the University of Pennsylvania in Philadelphia, PA (1997-1999), and Sussex University, Falmer, UK (1994-1997). I studied Cell and Developmental Biology at UC Irvine (PhD 1994), and Microbiology at UC Davis (MA 1986, BS 1984).